Tuesday's match was the latest masterclass from the South American trio, known in Spain as 'MSN', whose goals have put Barca on the brink of repeating 2009's treble of Champions League and Spanish league and Cup triumphs, the only time a La Liga club have achieved the feat.
Gareth Bale hailed a "perfect night" after his stunning winner for Real Madrid against Barcelona in Wednesday's King's Cup final, his first trophy since moving to Spain for a record fee in the close season.
News of all that's transpired on and off the football field
Manchester United dropped further down the table after losing 5-3 against newcomers Leicester City. Barcelona and Real Madrid scored 13 goals between them during a memorable La Liga weekend, when Cristiano Ronaldo netted a hat-trick.
A summary of Saturday's action in La Liga, Serie A and Bundesliga.
Barcelona closed in on the La Liga title by thrashing local rivals Espanyol 5-0 on Sunday as Atletico Madrid dropped out of the race after losing 2-1 at Levante and Real Madrid beat Valencia 3-2.
Barcelona provisionally went top of La Liga for the first time since October after Luis Suarez, Neymar and Lionel Messi scored in a 6-0 thrashing of Alaves on Saturday although the win was overshadowed by a serious injury to Aleix Vidal.
'It has been good on pitch and off pitch,' Lampard said.
Barcelona moved two points clear at the top of the table on Saturday after notching a 1-0 win at home to Real Sociedad while title challengers Sevilla beat Real Madrid 2-1.
News of all that's transpired on and off the football field
Sevilla and Real Madrid kept the pressure on leaders Barcelona with home wins in the Primera Liga on Sunday.
Cristiano Ronaldo believes Barcelona play better soccer than his Real Madrid side and has tipped Lionel Messi to win the 2009 Ballon d'Or.
Lionel Messi said his side were superior to every team in the league after he scored a hat-trick in Sunday's 4-2 win at Deportivo which clinched the club's 25th Spanish title with four games left in the season.
La Liga has been on hold since March 10 although president Javier Tebas said last week that the league could start up again on either May 29, June 7 or June 28, adding that the games were likely to be held without spectators. But Barcelona coach Quique Setien does not think it is so simple.
La Liga champions Barcelona slumped to a shock 2-1 defeat at struggling Leganes and Real Madrid were resoundingly beaten 3-0 by Sevilla on Wednesday as Spain's two biggest clubs lost on the same day for the first time since January, 2015.
Barca are now second on 66 points, two behind Real who have a game in hand as they chase a first title triumph since 2012.
Barcelona need to avoid getting sucked into the Spanish obsession with El Clasico when they face Ajax Amsterdam in the Champions League on Tuesday.
Barcelona coach Ronald Koeman has defended centre-back Gerard Pique's right to make comments about referees favouring Real Madrid.
Barca coach, Luis Enrique says that all is well at Camp Nou and the team is united.
When the dust has settled on Wednesday's shock Champions League exit at the hands of Atletico Madrid, one question that will be on the lips of many Barcelona fans is: where was Lionel Messi?
Barcelona rode their luck to come from behind and win 2-1 at Real Sociedad on Saturday, continuing to banish their awful record in San Sebastian and maintaining their perfect start to the La Liga season.
Ronaldinho was in inspirational form as he returned to lead Barcelona to a 5-1 home victory over an unfortunate Real Betis in the Primera Liga on Saturday.
The numbers behind Sunday's 'El Clasico' between Real Madrid and Barcelona at the Bernabeu stadium.
The result keeps Real Madrid in third spot in the Spanish first division standings, a point behind Valencia and five adrift of leaders Real Sociedad.
Barcelona are convinced Brazil captain Neymar will commit his long-term future to the Nou Camp as protracted negotiations between the Spanish champions and the striker continue over an extension to his current deal, which expires in June 2018.
Real Madrid's stuttering season continued as they were reduced to 10 men and then slumped to an 11th La Liga defeat of the campaign by going down 3-1 at Real Sociedad.
Lionel Messi will have another chance to match or surpass Telmo Zarra's six-decade-old La Liga scoring record of 251 goals when Barcelona host promoted Eibar on Saturday.
Real will ease the pain by retaining their Champions League title, their only hope of salvaging a disappointing season.
Barcelona restored their lead at the top of La Liga standings to nine points after Lionel Messi and Luis Suarez each scored in a routine if underwhelming 3-0 win at home to struggling Levante on Sunday, with Paulinho increasing their lead in added time.
Barcelona hit out at the referee and his assistants for failing to award Lionel Messi's first half 'goal' in an action-packed 1-1 draw at Liga title rivals Valencia on Sunday.
Bayern Munich will not only have to overturn a 3-0 Champions League semi-final first leg deficit against Barcelona on Tuesday but they will have to do it against a superb defence and in the midst of their biggest slump in years.
La Liga paupers Levante held big-spending visitors Real Madrid to a 0-0 draw on Saturday which is bound to put more pressure on new coach Jose Mourinho.
Cristiano Ronaldo and Gareth Bale both scored as Real Madrid staged a remarkable late comeback from two goals down to win 3-2 at Villarreal and stay top of La Liga.
Barcelona's Neymar scored twice and Luis Suarez was also on target as they reached their fourth King's Cup final in five years with a 3-1 win away to Villarreal on Wednesday that gave them a 6-2 aggregate victory.
The late equaliser saw Valencia left on eighth spot with 27 points in the standings. Here are Images from the exciting draw played at Mestalla in Valencia, on Sunday.
Barcelona moved six points clear at the top of La Liga by easing to a 4-0 win at home to Deportivo La Coruna on Sunday with doubles from Luis Suarez and Paulinho ahead of next week's 'Clasico' against champions Real Madrid.
Athletic Bilbao beat Barcelona 4-2 at home to knock them out of the Copa del Rey
Atletico Madrid will have centre backs Diego Godin and Stefan Savic available again for Tuesday's Champions League quarter-final first leg at Barcelona.
Neymar took time to settle but is finally shining in Barcelona's devastating attacking trident with Villarreal the next La Liga opponents in their sights on Sunday as the Catalans continue their pursuit of Real Madrid.